Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 3.034


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX3chr5_+_170736287-0.495.4e-02Click!
TLX1chr10_+_102891060-0.439.3e-02Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_102553343 13.670 NM_001031692
NM_005824
 LRRC17

leucine rich repeat containing 17

chr7_+_116165089 10.156 CAV1
caveolin 1, caveolae protein, 22kDa
chr7_+_116165043 10.078 NM_001172895
 CAV1
caveolin 1, caveolae protein, 22kDa
chr7_+_116164838 9.608 NM_001753
 CAV1
caveolin 1, caveolae protein, 22kDa
chr12_+_13349601 8.199 NM_001423
 EMP1
epithelial membrane protein 1
chr12_-_56106061 7.993 NM_001144997
 ITGA7
integrin, alpha 7
chr12_+_13349720 7.834 EMP1
epithelial membrane protein 1
chr9_+_139872014 7.345 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr1_-_173174611 7.187 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr8_-_42065037 6.978 PLAT
plasminogen activator, tissue
chr14_+_85996454 6.913 NM_013231
 FLRT2
fibronectin leucine rich transmembrane protein 2
chr8_-_42065193 6.708 NM_000930
NM_033011
 PLAT

plasminogen activator, tissue

chr21_+_46875402 6.539 NM_030582
 COL18A1
collagen, type XVIII, alpha 1
chr16_+_70502824 6.515 FUK
fucokinase
chr15_-_35087748 6.232 NM_005159
 ACTC1
actin, alpha, cardiac muscle 1
chrX_+_99899162 6.154 NM_014467
 SRPX2
sushi-repeat containing protein, X-linked 2
chr2_-_218843541 5.968 TNS1
tensin 1
chr9_+_139871954 5.280 NM_000954
 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr17_-_76921453 4.856 NM_003255
 TIMP2
TIMP metallopeptidase inhibitor 2
chr10_+_17271341 4.849 VIM
vimentin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 27 entries
Enrichment   P-value GO Accession GO Term
18.00 6.52e-04 GO:0030049 muscle filament sliding
18.00 6.52e-04 GO:0033275 actin-myosin filament sliding
17.53 7.68e-04 GO:0070252 actin-mediated cell contraction
15.24 2.46e-04 GO:0030048 actin filament-based movement
10.09 1.78e-04 GO:0006469 negative regulation of protein kinase activity
9.52 2.96e-04 GO:0033673 negative regulation of kinase activity
8.92 5.15e-04 GO:0051348 negative regulation of transferase activity
6.85 4.72e-03 GO:0001525 angiogenesis
5.82 6.01e-03 GO:0048514 blood vessel morphogenesis
5.27 5.32e-03 GO:0001568 blood vessel development
4.91 1.04e-02 GO:0001944 vasculature development
4.57 6.09e-04 GO:0048646 anatomical structure formation involved in morphogenesis
4.57 4.80e-02 GO:0030029 actin filament-based process
4.21 1.69e-03 GO:0072358 cardiovascular system development
4.21 1.69e-03 GO:0072359 circulatory system development
3.36 3.74e-03 GO:0007155 cell adhesion
3.36 3.74e-03 GO:0022610 biological adhesion
3.33 1.19e-03 GO:0009888 tissue development
3.03 3.52e-06 GO:0009653 anatomical structure morphogenesis
2.18 1.02e-02 GO:0048869 cellular developmental process

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
Enrichment   P-value GO Accession GO Term
25.61 2.45e-02 GO:0005865 striated muscle thin filament
13.88 2.34e-02 GO:0042641 actomyosin
9.57 2.12e-02 GO:0005604 basement membrane
7.93 3.39e-03 GO:0044420 extracellular matrix part
7.75 1.50e-02 GO:0030017 sarcomere
6.60 3.64e-02 GO:0044449 contractile fiber part
6.41 4.27e-02 GO:0030016 myofibril
5.44 2.27e-04 GO:0005578 proteinaceous extracellular matrix
5.15 4.05e-04 GO:0015629 actin cytoskeleton
4.88 2.77e-04 GO:0031012 extracellular matrix
4.45 7.72e-04 GO:0009986 cell surface
3.35 1.76e-04 GO:0005615 extracellular space
3.32 7.23e-06 GO:0044421 extracellular region part
2.58 1.62e-05 GO:0005576 extracellular region
2.15 4.98e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
8.17 4.00e-02 GO:0005201 extracellular matrix structural constituent
6.60 3.24e-02 GO:0019838 growth factor binding
4.39 9.70e-03 GO:0032403 protein complex binding
4.10 1.71e-02 GO:0003779 actin binding
3.77 9.55e-04 GO:0008092 cytoskeletal protein binding
3.08 1.75e-02 GO:0005198 structural molecule activity
1.33 4.45e-02 GO:0005515 protein binding